Natural course of metabolically healthy phenotype and risk of developing Cardiometabolic diseases: a three years follow-up study

Abstract Background Whether the metabolically healthy obese (MHO) phenotype is a single, stable or transitional, fluctuating state currently unknown. The Mexican-Mestizo population has genetic predisposition for development of type 2 diabetes (T2D) and other cardiometabolic complications. Little known about natural history metabolic health in this population. aim study was to analyze transitions over time among individuals with different degrees body mass index, evaluate incidence outcomes according phenotype. Methods consisted syndrome cohort at least 3 years follow up. Participants were apparently-healthy urban Mexican adults ?20 index (BMI) kg/m2. Metabolically defined using criteria National Cholesterol Education Program ( NCEP ) Adult Treatment Panel III ATP subjects stratified into 4 groups their BMI health. For we estimated standardized them per 1, 000 person-years follow-up. Finally, risk transition outcomes, fitted Cox Proportional Hazard regression models. Results Amongst 5541 subjects, 54.2% classified as 45.8% unhealthy. MHO prevalence 39.3%. Up third changed from initial category another higher rate observed (42.9%). We also found several novel factors associated unhealthy phenotype; socioeconomic status, number pregnancies, high carbohydrate intake, obesity consumption sweetened beverages. Similarly, visceral adipose tissue (VAT) main predictor transition; loss VAT ?5% reversion (hazard ratio (HR) 1.545, 95%CI 1.266–1.886). rates incident T2D hypertension (MUHO) lean (MUHL) phenotypes compared MHO. Conclusions Metabolic dynamic continuous process, time. It imperative establish effective processes primary care prevent such transitions.